A child was diagnosed as a case of pauci–immune crescentic glomerulonephritis. The treatment to be given in this child is –
**Core Concept**
Pauci-immune crescentic glomerulonephritis is a type of kidney inflammation characterized by the presence of crescents in the glomeruli and minimal immune complex deposition. It is often associated with **anti-neutrophil cytoplasmic antibody (ANCA)**-associated vasculitis. The underlying principle being tested is the treatment approach for this specific condition, which involves immunosuppression.
**Why the Correct Answer is Right**
The correct treatment involves immunosuppressive therapy to reduce inflammation and prevent further kidney damage. This typically includes **corticosteroids** and **cyclophosphamide** or other immunosuppressive agents. The goal is to induce remission and prevent progression to end-stage renal disease.
**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because it does not specify the use of immunosuppressive therapy.
**Option B:** Incorrect as it may not be the first line of treatment.
**Option D:** Incorrect because it is not the primary treatment approach.
**Clinical Pearl / High-Yield Fact**
Pauci-immune crescentic glomerulonephritis is a medical emergency requiring prompt initiation of immunosuppressive therapy to preserve kidney function.
**Correct Answer:** C. Corticosteroids and cyclophosphamide.