Patients suffering from multidrug-resistant tuberculosis can be treated with all the following drugs EXCEPT :
**Core Concept**
Multidrug-resistant tuberculosis (MDR-TB) is a form of TB that is resistant to at least isoniazid and rifampicin, the two most effective first-line anti-TB drugs. Treatment of MDR-TB requires a combination of second-line anti-TB drugs.
**Why the Correct Answer is Right**
The treatment of MDR-TB involves the use of second-line anti-TB drugs such as aminoglycosides, polypeptides, thioamides, and fluoroquinolones. These drugs work by inhibiting the growth of TB bacteria or by killing them directly. For example, aminoglycosides such as kanamycin and amikacin work by binding to the bacterial ribosome and inhibiting protein synthesis. Fluoroquinolones such as moxifloxacin and levofloxacin work by inhibiting DNA gyrase and topoisomerase IV, which are essential enzymes for DNA replication and transcription.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is actually one of the second-line anti-TB drugs used to treat MDR-TB.
**Option B:** This option is incorrect because it is actually one of the second-line anti-TB drugs used to treat MDR-TB.
**Option D:** This option is incorrect because it is actually one of the second-line anti-TB drugs used to treat MDR-TB.
**Clinical Pearl / High-Yield Fact**
It is essential to note that the treatment of MDR-TB is complex and requires a combination of second-line anti-TB drugs. The treatment regimen should be individualized based on the patient's drug susceptibility pattern and clinical response.
**Correct Answer: A. Isoniazid and Rifampicin are the first-line anti-TB drugs that are ineffective against MDR-TB.