Lipoprotein associated with carrying cholesterol from periphery tissues to liver is ?
**Core Concept**
The question is testing the understanding of lipoprotein metabolism, specifically the transport of cholesterol from peripheral tissues to the liver. This process involves the activation of enzymes and receptors that facilitate the uptake and clearance of cholesterol from the bloodstream.
**Why the Correct Answer is Right**
The correct answer is a lipoprotein that plays a key role in reverse cholesterol transport, where it carries excess cholesterol from peripheral tissues to the liver for excretion. This process is mediated by the enzyme cholesterol ester transfer protein (CETP) and the receptor scavenger receptor class B type I (SR-BI). The lipoprotein in question is rich in apolipoproteins A-I and A-II, which facilitate the binding of the lipoprotein to the SR-BI receptor on hepatocytes.
**Why Each Wrong Option is Incorrect**
**Option A:** Apolipoprotein B-100 is primarily found on low-density lipoproteins (LDL), which transport cholesterol from the liver to peripheral tissues, not the other way around.
**Option B:** Very-low-density lipoproteins (VLDL) are produced in the liver and transport endogenous triglycerides to peripheral tissues, not excess cholesterol from the periphery to the liver.
**Option C:** High-density lipoproteins (HDL) are indeed involved in reverse cholesterol transport, but the correct answer is a specific type of HDL that is more directly involved in this process.
**Clinical Pearl / High-Yield Fact**
The term "good" cholesterol refers to HDL, which is involved in reverse cholesterol transport and is associated with a reduced risk of cardiovascular disease.
**Correct Answer:** C. High-density lipoprotein (HDL)