Association of sexual precocity, multiple cystic bone lesions and endocrinopathies are seen in –
**Core Concept**
The question is testing the association of a rare genetic disorder characterized by premature sexual development, skeletal abnormalities, and endocrine system dysfunction. This condition is caused by mutations in a specific gene that affects multiple organ systems.
**Why the Correct Answer is Right**
The correct answer is associated with McCune-Albright syndrome, a rare genetic disorder caused by activating mutations in the GNAS gene. This mutation leads to the overexpression of G-protein alpha subunits, affecting various tissues including osteoblasts, chondrocytes, and endocrine cells. The resulting clinical features include premature sexual development, multiple cystic bone lesions (fibrous dysplasia), and various endocrinopathies such as hyperthyroidism, Cushing's syndrome, and acromegaly.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not match the clinical features of McCune-Albright syndrome. The other options, **Option B**, **Option C**, and **Option D**, are incorrect as well because they are not associated with the specific combination of sexual precocity, multiple cystic bone lesions, and endocrinopathies described in the question.
**Clinical Pearl / High-Yield Fact**
McCune-Albright syndrome is characterized by the classic triad of café-au-lait skin spots, fibrous dysplasia, and endocrine system dysfunction. It is essential to recognize this syndrome in patients presenting with these features to provide appropriate management and genetic counseling.
**Correct Answer:**
McCune-Albright syndrome