Following antineoplastic drugs should not be administered to a chronic alcoholic patient due to risk of development disulfiram like reaction
**Core Concept**
The question is testing the knowledge of a disulfiram-like reaction, which is a condition where certain medications interact with alcohol, causing an adverse reaction. This reaction is often seen with antineoplastic drugs that inhibit aldehyde dehydrogenase, an enzyme responsible for metabolizing acetaldehyde, a toxic byproduct of alcohol metabolism.
**Why the Correct Answer is Right**
The correct answer is a medication that inhibits aldehyde dehydrogenase, leading to a buildup of acetaldehyde when combined with alcohol. This results in a disulfiram-like reaction, characterized by symptoms such as facial flushing, sweating, nausea, and headaches. Medications like disulfiram are used to treat chronic alcoholism, and other antineoplastic drugs that inhibit aldehyde dehydrogenase can cause similar reactions.
**Why Each Wrong Option is Incorrect**
* **Option A:** This medication does not inhibit aldehyde dehydrogenase and is not associated with a disulfiram-like reaction.
* **Option B:** This option is a correct antineoplastic drug but is not the one that should not be administered to a chronic alcoholic patient due to risk of development disulfiram like reaction.
* **Option D:** This medication is not commonly associated with a disulfiram-like reaction and is not a correct answer.
**Clinical Pearl / High-Yield Fact**
When managing chronic alcoholic patients, it's essential to be aware of medications that can trigger a disulfiram-like reaction. This includes antineoplastic drugs that inhibit aldehyde dehydrogenase, which can lead to severe adverse reactions when combined with alcohol.
**Correct Answer:** C.