**Question:** After use of some drug, a person develops episodes of rage in which he runs about and indiscriminately injures a person who is encountered in his way. He is probably addicted to

A. Methamphetamine
B. Cocaine
C. Heroin
D. Nicotine

**Correct Answer:** A. Methamphetamine

**Core Concept:** Methamphetamine is a central nervous system stimulant that alters mood, behavior, and cognition. It is a Schedule II controlled substance in the United States and has hallucinogenic and euphoria-inducing effects.

**Why the Correct Answer is Right:** Methamphetamine is responsible for the rage episodes described in the scenario. When abused, it leads to toxic levels of dopamine release, causing hyperactivity, agitation, and a heightened sense of aggression. In these cases, the individual may act impulsively and without discrimination, leading to injury to others.

**Why Each Wrong Option is Incorrect:**

A. Cocaine: Although cocaine also stimulates the central nervous system, it does not typically induce rage episodes or aggression. It primarily affects the cardiovascular and respiratory systems.

B. Heroin: Unlike methamphetamine, heroin is a depressant and causes sedation, respiratory depression, and reduced motor function. It is not associated with rage episodes or aggression.

C. Nicotine: Nicotine is a stimulant, but it is primarily associated with nicotine withdrawal symptoms like irritability, anxiety, and restlessness when a smoker attempts to quit or reduce tobacco use. It is not typically linked to rage episodes or aggression.

**Clinical Pearl:** Understanding the pharmacological effects of different drugs is essential for healthcare professionals, as it helps in assessing patients' behavioral changes and potential drug-related issues. Prompt recognition and treatment of these changes can prevent harm to the patient and others.