If a thiazide diuretic is administered for hypertension, the response seen within 24 hrs on excretion of different electrolytes is:
**Core Concept**
The administration of thiazide diuretics for hypertension management leads to a characteristic pattern of electrolyte excretion within the first 24 hours. Thiazides act by inhibiting the sodium-chloride cotransporter in the distal convoluted tubule, resulting in increased sodium and chloride excretion.
**Why the Correct Answer is Right**
Thiazides cause a significant increase in the excretion of sodium (Na+), chloride (Cl-), and potassium (K+) ions within 24 hours. This is due to the inhibition of the sodium-chloride cotransporter (NCC) in the distal convoluted tubule, which normally reabsorbs sodium and chloride ions back into the bloodstream. As a result, the filtered load of sodium and chloride ions is increased, leading to increased excretion. Additionally, the increased sodium delivery to the collecting duct promotes the secretion of potassium ions, leading to increased potassium excretion. The increased sodium delivery also leads to increased calcium excretion.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not provided.
* **Option B:** This option is not provided.
* **Option C:** This option is not provided.
**Clinical Pearl / High-Yield Fact**
Thiazides cause a mild to moderate increase in uric acid levels due to decreased uric acid excretion, which can be a concern in patients with gout.
**Correct Answer: C. Increased excretion of sodium, chloride, and potassium ions.**