**Core Concept:** Desogestrel is a progestogen, a type of hormone used in hormonal contraceptives like the minipill. Minipills typically contain lower doses of progestogens than combined oral contraceptives (COCs).

**Why the Correct Answer is Right:** The correct answer is D (once daily) because desogestrel, being a progestogen, is primarily responsible for preventing ovulation and thickening cervical mucus to hinder sperm entry. In the minipill, desogestrel's lower dose (75 µg) allows for once daily administration, ensuring efficacy without the side effects commonly seen with higher dose COCs (e.g., breast tenderness, weight gain, and mood changes).

**Why Each Wrong Option is Incorrect:**

A. Minipills containing 75 µg of desogestrel are not administered twice daily, as this would increase the risk of side effects without any significant improvement in contraceptive efficacy.

B. Twice daily administration is incorrect because it would lead to higher systemic concentrations of desogestrel, increasing the chances of side effects without a substantial improvement in contraceptive effectiveness.

C. Minipills are designed to be taken once daily, not three times daily. Tricking the system by mentioning three doses does not align with the actual dosing regimen.

**Clinical Pearl:** The correct dosing of progestogen-only pills, including minipills, is crucial for patient safety and compliance. A once daily dose minimizes side effects but ensures contraceptive efficacy, making this regimen essential for patients seeking a simple, low-risk contraceptive option.