MCardle’s syndrome is due to
Correct Answer: Deficiency of glucose-6-phosphatase
Description: McArdle disease (also known as glycogen storage disease type V) is a disorder affecting muscle metabolism. The condition is caused by the lack of an enzyme called muscle phosphorylase. This results in an inability to break down glycogen 'fuel' stores. McArdle disease leads to pain and fatigue with strenuous exercise. Ref Robbins 9/e pg 153
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