MC cause of anovulation is-
**Core Concept**
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting ovulation, often associated with hormonal imbalances and insulin resistance. The pathophysiology of PCOS involves disrupted gonadotropin-releasing hormone (GnRH) secretion, leading to altered luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels.
**Why the Correct Answer is Right**
The primary cause of anovulation in PCOS is the hypersecretion of LH, which disrupts the normal follicular development and ovulation process. This is often accompanied by insulin resistance, contributing to the development of hyperandrogenism. The elevated LH levels stimulate the androgen-producing theca cells in the ovaries, leading to increased androgen production and subsequent anovulation.
**Why Each Wrong Option is Incorrect**
* **Option A:** Not enough information is provided to determine the validity of this option.
* **Option B:** This option is incorrect as it is not a primary cause of anovulation in PCOS.
* **Option C:** This option is incorrect as it is not a direct cause of anovulation in PCOS.
**Clinical Pearl / High-Yield Fact**
PCOS is often associated with insulin resistance, and metformin, a medication that improves insulin sensitivity, is commonly used in the management of PCOS to induce ovulation and improve menstrual regularity.
**Correct Answer:** C.