Medical MCQ-Maternal serum Alpha-fetoprotein is raised in all the following conditions EXCEPT:

Maternal serum Alpha-fetoprotein is raised in all the following conditions EXCEPT:

Spina bifida

Multiple pregnancy

Omphalocele

Down's syndrome

Question Category:

Gynaecology & Obstetrics

Correct Answer:

Down's syndrome

Description:

Ans. D. Down's syndromeCauses of Raised MSAFPa. Upper GI obstructionb. Wrong dates (under-estimation)c. Obstructive uropathyd. NTDe. Feto-maternal haemorrhagef. Congenital nephrosisg. CAML (Cystic adenomatoid malformation of the lung)h. Placental/cord tumorsi. Sacrococcygeal teratomaj. Multiple pregnancyk. Maternal liver diseasel. Male fetuses have higher MSAFPm. Abdominal wall defectsn. Afro-Caribbean ethnic backgroundo. Associated with increased risk of IUD/PPROM/IUGR/oligohydramnios/pre-eclampsiap. Smoking

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