## Core Concept
Botryomycosis is a chronic bacterial infection caused by *Staphylococcus aureus*, resembling a fungal infection due to its clinical presentation. It primarily affects the skin and subcutaneous tissue. The condition is characterized by the formation of granules that resemble fungal elements.

## Why the Correct Answer is Right
The correct statement about botryomycosis is related to its causative agent and clinical presentation. *Staphylococcus aureus* is the most common cause, and it presents with features similar to mycetoma (a fungal infection), including the formation of granules. These granules are actually bacterial aggregates.

## Why Each Wrong Option is Incorrect
- **Option A:** If option A states that botryomycosis is caused by a fungus, this is incorrect because botryomycosis is caused by bacteria, specifically *Staphylococcus aureus*.
- **Option B:** If option B mentions that the infection typically presents with systemic symptoms early on, this might be misleading as botryomycosis usually presents as a localized infection.
- **Option C:** Without specific details on option C, we assume it might provide a correct or partially correct statement about botryomycosis, given that D is marked as the correct answer.
- **Option D:** If option D accurately describes a characteristic of botryomycosis, such as its chronic nature, resemblance to a fungal infection, or its causative organism, then it would be correct.

## Clinical Pearl / High-Yield Fact
A key point to remember is that botryomycosis is often misdiagnosed as a fungal infection due to its similar clinical presentation, including the formation of granules. However, it is crucial to identify the causative organism, *Staphylococcus aureus*, for appropriate antibiotic therapy.

## Correct Answer: D.