MAO inhibitors should not be used with:
Correct Answer: Pethidine
Description: Pethidine should be avoided in patients receiving MAO inhibitors, because both these drugs can result in very high levels of serotonin. MAOI inhibits breakdown of serotonin and pethidine inhibits reuptake of serotonin. This result in excess excitation characterized by agiation, delirium, headache, rigidity, hyperpyrexia and coma. When both of these drugs are used together respiratory, cardiovascular depression and coma can result due to the inhibition of hepatic microsomal enzymes by MAOI, resulting in an increase in the level of pethidine. Ref: Essentials of Medical Pharmacology By KD Tripathi, 5th Edition, Page 431 - 2
Category:
Pharmacology
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