Mantle cell Ca shows –
**Core Concept**
Mantle cell lymphoma is a type of non-Hodgkin lymphoma characterized by the **t(11;14) chromosomal translocation**, leading to overexpression of **cyclin D1**. This results in uncontrolled cell proliferation. The disease often presents with lymphadenopathy, splenomegaly, and bone marrow involvement.
**Why the Correct Answer is Right**
The correct answer is related to the characteristic genetic and molecular features of mantle cell lymphoma. The **t(11;14) translocation** involves the **CCND1** gene, which encodes **cyclin D1**, and the **IGH** gene on chromosome 14. This translocation leads to the overexpression of **cyclin D1**, driving the cell cycle forward and contributing to lymphomagenesis.
**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because it is not specifically associated with mantle cell lymphoma.
**Option B:** Incorrect as it is more commonly linked to other types of lymphoma.
**Option C:** Incorrect because, although it involves genetic alterations, it is not the hallmark of mantle cell lymphoma.
**Why Each Wrong Option is Incorrect (Continued)**
**Option D:** Incorrect as it does not accurately describe the primary genetic anomaly in mantle cell lymphoma.
**Clinical Pearl / High-Yield Fact**
Mantle cell lymphoma is known for its aggressive clinical course and poor response to therapy, making early diagnosis crucial. The **cyclin D1** overexpression is a diagnostic hallmark and can be used to distinguish mantle cell lymphoma from other lymphoid neoplasms.
**Correct Answer:** D. t(11;14) translocation