Manifestations of vitamin C deficiency are – a) Pseudoparalysisb) Sabre tibiac) Epistaxisd) Craniotabese) Costochondral junction become domeshaped

**Core Concept**
Vitamin C deficiency leads to impaired collagen synthesis, causing connective tissue damage, and various manifestations. Ascorbic acid is essential for hydroxylation of proline and lysine in collagen, and its deficiency results in scurvy, characterized by impaired wound healing, joint pain, and bleeding gums.

**Why the Correct Answer is Right**
Option A: Pseudoparalysis is a manifestation of scurvy, particularly in children, where muscle weakness and joint pain mimic paralysis. This is due to the impaired collagen synthesis affecting the connective tissue surrounding muscles and joints.
Option B: Sabre tibia is a classic radiological finding in scurvy, where the tibia appears widened due to the impaired bone growth and collagen synthesis.
Option C: Epistaxis is a manifestation of vitamin C deficiency, as impaired collagen synthesis affects the blood vessel walls, leading to bleeding.
Option D: Craniotabes is a manifestation of scurvy, where the bones of the skull become soft and spongy due to impaired collagen synthesis.
Option E: Costochondral junction becoming domeshaped is not a characteristic manifestation of vitamin C deficiency.

**Why Each Wrong Option is Incorrect**
**Option A:** Not directly related to vitamin C deficiency.
**Option B:** While costochondral junctions can be affected, sabre tibia is more specific to scurvy.
**Option C:** Not a direct manifestation of vitamin C deficiency; epistaxis can be related to other causes.
**Option D:** Not a characteristic finding of scurvy; craniotabes is more specific.
**Option E:** Not a manifestation of vitamin C deficiency.

**Clinical Pearl / High-Yield Fact**
Remember the classic triad of scurvy: **Bleeding gums**, **Joint pain**, and **Impaired wound healing**.

**Correct Answer: A. Pseudoparalysis**