Most common extra skin manifestation of varicella is involvement of ?
**Core Concept:** Varicella is a viral infection caused by the varicella-zoster virus (VZV), which is the same virus that causes chickenpox. The infection typically presents as a localized rash involving the skin and sometimes the mucous membranes. Extra-cutaneous manifestations can occur in some cases, affecting various organs.
**Why the Correct Answer is Right:** Involvement of the liver (ICP) is the most common extra-cutaneous manifestation of varicella, as evidenced by elevated liver enzymes and increased serum bilirubin levels. Hepatitis can occur due to the virus's direct invasion of hepatocytes, causing inflammation and damage.
**Why Each Wrong Option is Incorrect:**
A. Striate palms and soles: While varicella can affect the skin in this way, it is less common than liver involvement.
B. Soft palate: Varicella rarely affects the soft palate, making it an unlikely answer.
C. Bone marrow: Virus can infect bone marrow, but liver involvement is more common and more severe.
D. Heart: Although VZV can infect the heart, its involvement is less common than liver involvement.
**Clinical Pearl:** Monitoring liver function tests (LFTs) during and after chickenpox is crucial, as elevated liver enzymes can indicate severe liver involvement and may require antiviral therapy.
**Correct Answer:** IC (Involvement of the liver)