**Core Concept**
Locally advanced cervical cancer, such as FIGO stage 2-3, requires a multimodal treatment approach that combines radiotherapy and chemotherapy to optimize outcomes. This approach aims to control the primary tumor, address potential microscopic spread, and alleviate symptoms.

**Why the Correct Answer is Right**
Radiotherapy plays a crucial role in managing locally advanced cervical cancer by eradicating cancer cells within the primary tumor site. Chemotherapy complements radiotherapy by addressing potential microscopic disease spread, thereby improving survival rates and reducing recurrence risk. The combination of radiotherapy and chemotherapy is a standard treatment approach for locally advanced cervical cancer, as evidenced by numerous clinical trials and guidelines. The concurrent administration of chemotherapy and radiotherapy, known as chemoradiation, has been shown to improve outcomes compared to radiotherapy alone.

**Why Each Wrong Option is Incorrect**
**Option A:** Surgery plus chemotherapy may be considered for early-stage cervical cancer, but it is not the preferred treatment for locally advanced disease, which often involves more extensive tumor involvement and potential lymph node metastasis.

**Option C:** Chemotherapy alone is not sufficient to manage locally advanced cervical cancer, as it does not address the primary tumor site effectively. Chemoradiation is the preferred approach to ensure optimal tumor control.

**Option D:** Radiotherapy plus HPV vaccine is not a standard treatment approach for cervical cancer, as the HPV vaccine is primarily used for primary prevention of HPV infections and cervical cancer in individuals who have not been previously exposed to HPV.

**Clinical Pearl / High-Yield Fact**
The concurrent administration of chemotherapy and radiotherapy (chemoradiation) is a key component of managing locally advanced cervical cancer. This approach has been demonstrated to improve survival rates and reduce recurrence risk in numerous clinical trials.

**✓ Correct Answer: B. Radiotherapy plus chemotherapy**