The most common histopathological type of malignant melanoma of choroid is:
**Question:** The most common histopathological type of malignant melanoma of choroid is:
A. Spindle cell type
B. Lentigo maligna type
C. Superficial spreading type
D. Acral lentiginous type
**Core Concept:**
Malignant melanoma is a type of skin cancer that can also develop in other parts of the body, such as the choroid (the innermost layer of the eye). When malignant melanoma occurs in the choroid, it is usually a result of the spread of melanoma from other parts of the body or the development of melanoma de novo (from the beginning). The histopathological types refer to the pattern of cell growth and spread within the affected tissue.
**Why the Correct Answer is Right:**
The correct answer is B. Lentigo maligna type, also known as lentigo maligna melanoma (LMM). This type of malignant melanoma of choroid presents with a flat, brownish macule with a well-defined border and a distinct zone of atypical melanocytes. It develops from pre-existing benign lesions, known as lentigines or age spots, which are caused by chronic sun exposure. Lentigo maligna is a slow-growing type, and early detection and management are crucial to improve the prognosis.
**Why Each Wrong Option is Incorrect:**
A. Spindle cell type (acral lentiginous) - This type of malignant melanoma typically develops on the palms, soles, or other acral or mucosal sites and is characterized by spindle-shaped cells. It is less common in the choroid.
C. Superficial spreading type - This type of malignant melanoma is characterized by the spread of cells from the basal layer to the epidermis and is mainly seen in the skin. It is less common in the choroid.
D. Acral lentiginous type - Similar to option A, the acral lentiginous type is associated with the skin and not commonly found in the choroid.
**Clinical Pearl:**
Lentigo maligna is a subtype of malignant melanoma that should always be suspected in patients with a history of chronic sun exposure, particularly those who have had a pre-existing lentigo or age spot. Early detection and management are crucial for better prognosis. Clinical examination and appropriate imaging studies can aid in the diagnosis of lentigo maligna.