Psychiatry Major depression is thought to be caused by changes in: A Histamine synapses in the Basal Ganglia B Monoamine synapses in the Basal Ganglia C GABA synapses in the Cerebellum D Monoamine synapses in the Limbic System 💡 Explanation Major depression is thought to be caused by changes in: ✓ Correct Answer: D. Monoamine synapses in the Limbic System