Pharmacology Maintenance of high urinary pH is important during methotrexate treatment because: A Bladder irritation is reduced B It decreases renal tubular secretion of methotrexate C Leucovorin toxicity is increased in a dehydrated patient D Methotrexate is a weak acid 💡 Explanation Maintenance of high urinary pH is important during methotrexate treatment because: ✓ Correct Answer: D. Methotrexate is a weak acid