Maintenance of high urinary pH is important during methotrexate treatment because:
Correct Answer: Methotrexate is a weak acid
Description: Methotrexate is a weak acid and is reabsorbed in acidic urinary pH. Higher plasma concentration may result in toxicity. Therefore, to decrease the reabsorption through renal tubules, high urinary pH must be maintained.
Category:
Pharmacology
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