**Core Concept**
The lyre sign is a radiological feature observed in the context of a specific medical condition. It refers to a characteristic appearance of the aortic arch and descending aorta on imaging studies, which resembles a musical instrument called a lyre. This sign is associated with a congenital anomaly of the aortic arch.

**Why the Correct Answer is Right**
The lyre sign is seen in patients with a right-sided aortic arch, which is a rare congenital anomaly of the aorta. In this condition, the aortic arch arises from the right side of the aortic root and descends on the right side of the trachea, giving it a characteristic "lyre-like" shape on imaging studies. This anomaly can be associated with other congenital heart defects and is often diagnosed on chest X-rays or CT scans.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because the lyre sign is not typically associated with a left-sided aortic arch, which is the more common normal anatomy.
**Option B:** This option is incorrect because the lyre sign is not a characteristic feature of coarctation of the aorta, although both conditions can involve narrowing of the aorta.
**Option C:** This option is incorrect because the lyre sign is not associated with an aberrant right subclavian artery, which is a different congenital anomaly of the aortic arch.

**Clinical Pearl / High-Yield Fact**
The lyre sign should be considered in patients with a suspected congenital heart defect or aortic anomaly, especially if there is an abnormality of the aortic arch or descending aorta on imaging studies.

**Correct Answer:** D.