Mantle cell lymphoma shows-
**Core Concept**
Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma characterized by the accumulation of malignant B cells expressing cyclin D1 due to a chromosomal translocation involving the CCND1 gene. This genetic abnormality leads to uncontrolled cell proliferation.
**Why the Correct Answer is Right**
MCL is characterized by a specific chromosomal translocation, t(11;14)(q13;q32), which results in the juxtaposition of the CCND1 gene encoding cyclin D1 with the immunoglobulin heavy chain locus. This leads to the overexpression of cyclin D1, driving cell cycle progression and contributing to lymphomagenesis. The cyclin D1 protein is a key regulator of the G1-S phase transition in the cell cycle.
**Why Each Wrong Option is Incorrect**
**Option A:** Not applicable, as this option is missing.
**Option B:** Incorrect, as follicular lymphoma is characterized by a different genetic abnormality, t(14;18)(q32;q21), leading to the overexpression of Bcl-2.
**Option C:** Incorrect, as diffuse large B-cell lymphoma is a heterogeneous group of lymphomas with various underlying genetic abnormalities, but not specifically associated with cyclin D1 overexpression.
**Option D:** Incorrect, as Burkitt lymphoma is characterized by a distinct genetic abnormality, t(8;14)(q24;q32), leading to the overexpression of c-Myc.
**Clinical Pearl / High-Yield Fact**
Mantle cell lymphoma often presents with systemic symptoms such as weight loss, night sweats, and fatigue, and may involve lymph nodes, spleen, and other extranodal sites, including the gastrointestinal tract, skin, and central nervous system.
**Correct Answer:** B. Follicular lymphoma.