Necrotising lymphadenitis is seen with
**Core Concept**
Necrotizing lymphadenitis refers to a form of lymph node inflammation characterized by necrosis of lymphoid cells and histiocytes. This condition is often associated with systemic symptoms such as fever and malaise, and can be seen in various infectious and autoimmune diseases.
**Why the Correct Answer is Right**
Kikuchi disease, also known as histiocytic necrotizing lymphadenitis, is a rare, self-limiting condition that typically affects young women. It is characterized by lymph node enlargement and necrosis of lymphoid cells and histiocytes, which is a hallmark of the disease. The exact pathogenesis of Kikuchi disease is not well understood, but it is thought to involve an autoimmune response to an infectious agent. The condition is often associated with systemic symptoms such as fever, malaise, and lymphadenopathy.
**Why Each Wrong Option is Incorrect**
**Option A:** Kimura disease is a rare, chronic inflammatory disorder that affects the lymph nodes and subcutaneous tissue, but it is not typically associated with necrotizing lymphadenitis.
**Option C:** Castleman disease is a rare disorder characterized by lymph node enlargement and systemic symptoms, but it is not typically associated with necrotizing lymphadenitis.
**Option D:** Hodgkin's lymphoma is a type of lymphoma that can cause lymph node enlargement and systemic symptoms, but it is not typically associated with necrotizing lymphadenitis.
**Clinical Pearl / High-Yield Fact**
Kikuchi disease is often misdiagnosed as tuberculosis or lymphoma due to its similar clinical presentation, but it has a distinct histopathological appearance characterized by necrosis of lymphoid cells and histiocytes.
**β Correct Answer: B. Kikuchi disease**