Compared to follicular Ca, papillary Ca of thyroid have :a) More male preponderanceb) Bilateralityc) Local recurrence commond) Increased mortalitye) Increased lymph node metastasis.
**Core Concept**
Papillary thyroid carcinoma (PTC) is the most common thyroid cancer, characterized by a strong female predominance, frequent bilateral involvement, and low mortality despite lymph node metastasis. In contrast, follicular thyroid carcinoma (FTC) is more common in males and has a higher risk of local recurrence and mortality.
**Why the Correct Answer is Right**
Papillary thyroid cancer shows **bilateral involvement** (b), due to its diffuse nature and tendency to spread bilaterally. It has **increased lymph node metastasis** (e), especially in the cervical lymph nodes, which is a key feature. While local recurrence is less common than in follicular carcinoma, **local recurrence** (c) is still a known risk, especially in advanced or large tumors. However, **increased mortality** (d) is not true — PTC has one of the best prognoses among thyroid cancers. Male preponderance (a) is false — PTC is more common in females. Thus, b, c, and e are correct.
**Why Each Wrong Option is Incorrect**
Option A: Male preponderance is false — PTC is more common in females.
Option C: Local recurrence is less common in PTC than in FTC; thus, "common" is incorrect.
Option D: Increased mortality is false — PTC has excellent survival rates, unlike follicular carcinoma.
**Clinical Pearl / High-Yield Fact**
Papillary thyroid cancer is the most common thyroid cancer, with a female-to-male ratio of ~3:1, frequent bilateral spread, and high lymph node metastasis — but **low mortality** and **excellent prognosis**. Always remember: "Papillary = female, bilateral, lymph node spread, low mortality."
✓ Correct Answer: B. bce