Lymph node biopsy of an AIDS patient shows: March 2009
**Core Concept**
The lymph node biopsy in an AIDS patient reveals characteristic histopathological features due to the immunocompromised state and the presence of the human immunodeficiency virus (HIV). This situation leads to a combination of changes in the lymph node architecture and cellular composition.
**Why the Correct Answer is Right**
The correct answer is D. All of the above because an AIDS patient's lymph node biopsy can exhibit multiple characteristic features. Wahin-Finkeldey cells are giant cells with a characteristic 'owl-eyed' appearance, which are seen in lymph nodes of patients with HIV infection. Marked follicular hyperplasia is a common finding in the lymph nodes of individuals with HIV/AIDS, resulting from the body's attempt to counteract the viral infection. The 'moth-eaten appearance' of lymph nodes in AIDS patients is due to the destruction of lymphoid cells and the replacement of these areas with fibrous tissue.
**Why Each Wrong Option is Incorrect**
**Option A:** Wahin-Finkeldey cells are specific to HIV infection, but they are not the only feature present in an AIDS patient's lymph node biopsy.
**Option B:** Marked follicular hyperplasia is indeed a feature of AIDS, but it is not the only characteristic change seen in the lymph nodes of these patients.
**Option C:** The 'moth-eaten appearance' is a specific feature of AIDS, but it is not the only characteristic feature present in an AIDS patient's lymph node biopsy.
**Clinical Pearl / High-Yield Fact**
In the context of AIDS, lymph node biopsy findings can provide valuable insights into the progression of the disease. A combination of Wahin-Finkeldey cells, marked follicular hyperplasia, and a 'moth-eaten appearance' can help confirm the diagnosis of AIDS.
**β Correct Answer: D. All of the above**