**Core Concept**
The question tests the understanding of probability and odds in the context of disease development, specifically **lung cancer**. Probability and odds are measures of chance, with probability being the number of favorable outcomes divided by the total number of outcomes, and odds being the ratio of the probability of an event happening to the probability of it not happening.

**Why the Correct Answer is Right**
Given a lifetime probability of developing **lung cancer** is 25%, or 0.25, the odds in favor can be calculated using the formula: odds = probability / (1 - probability). Therefore, the odds = 0.25 / (1 - 0.25) = 0.25 / 0.75 = 1/3. This means the odds of developing **lung cancer** in a lifetime are 1 to 3, or **1:3**.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not correctly represent the odds calculated from the given probability.
**Option B:** Similarly, this option does not match the calculated odds.
**Option D:** This option is also incorrect as it does not represent the odds of 1 to 3.

**Clinical Pearl / High-Yield Fact**
It's crucial to understand the difference between probability and odds, especially in **epidemiology** and **clinical practice**, as these measures are fundamental to understanding and communicating **risk**.

**Correct Answer:** 1:3