Lubiprostone is a:
Correct Answer: Chloride channel activator
Description: Lubiprostone :- selectively stimulates type 2 chloride channels in epithelial cells thereby causing an efflux of chloride into the intestinal lumen. - The resultant fluid secretion into the gastrointestinal lumen provides a bolus effect that softens stool, increases intestinal transit, and improves symptoms of constipation. - Lubiprostone acts locally within the intestinal tract, is rapidly metabolized, and has very low systemic bioavailability.
Category:
Pharmacology
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