**Core Concept**
Iridocorneal endothelial (ICE) syndrome is a rare, non-familial disorder characterized by the proliferation of corneal endothelial cells, leading to abnormal adhesion and eventual destruction of the iris and cornea. This condition is often associated with glaucoma and vision loss due to the disruption of the normal corneal endothelial function.
**Why the Correct Answer is Right**
The correct answer is associated with **Fuchs' endothelial dystrophy**. Fuchs' endothelial dystrophy is a progressive disorder of the corneal endothelium, leading to corneal edema, vision loss, and eventually, glaucoma. The pathophysiology of Fuchs' endothelial dystrophy involves the abnormal proliferation and migration of corneal endothelial cells, which can lead to the formation of iris lesions and the development of ICE syndrome.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not relevant to ICE syndrome.
* **Option B:** This option is not a recognized association with ICE syndrome.
* **Option D:** This option is not a known complication of ICE syndrome.
**Clinical Pearl / High-Yield Fact**
Fuchs' endothelial dystrophy is a common cause of corneal endothelial dysfunction, and early recognition is crucial to prevent vision loss. Corneal transplantation is often required to restore vision in advanced cases.
**Correct Answer:** B. Fuchs' endothelial dystrophy.
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