Lordaceous spleen is seen in –
**Core Concept**
The question is testing the student's knowledge of the histopathological features associated with amyloidosis, a condition characterized by the deposition of amyloid fibrils in various tissues. The term "Lordaceous spleen" refers to a specific type of splenic pathology.
**Why the Correct Answer is Right**
The correct answer is D. Diffuse amyloidosis. In this condition, amyloid fibrils accumulate diffusely throughout the spleen, leading to its enlargement and a characteristic "Lordaceous" appearance. This is due to the deposition of amyloid fibrils in the splenic pulp and sinuses, which disrupts the normal architecture of the spleen. The amyloid deposits in diffuse amyloidosis are typically composed of light chains, such as lambda or kappa, which are produced by clonal plasma cells.
**Why Each Wrong Option is Incorrect**
**Option A:** Alcoholic hepatitis is a condition that affects the liver, characterized by inflammation and damage to liver cells. It does not typically affect the spleen or cause a "Lordaceous" appearance.
**Option B:** Chronic active hepatitis is a type of liver inflammation that can lead to cirrhosis and scarring. While it can cause splenomegaly (enlargement of the spleen), it is not typically associated with a "Lordaceous" appearance.
**Option C:** Focal amyloidosis refers to the deposition of amyloid fibrils in a localized area, such as a particular organ or tissue. While it can cause significant pathology, it is not typically associated with a diffuse "Lordaceous" appearance in the spleen.
**Clinical Pearl / High-Yield Fact**
Remember that amyloidosis can affect multiple organs, including the kidneys, heart, and nervous system, in addition to the spleen. A high index of suspicion is necessary to diagnose amyloidosis, as it can present with a range of non-specific symptoms.
**β Correct Answer: D. Diffuse amyloidosis**