**Core Concept**
Nephrotic syndrome is characterized by severe proteinuria, hypoalbuminemia, and edema. Long-term use of corticosteroids can lead to various side effects and complications. This question requires an understanding of the potential consequences of prolonged corticosteroid therapy in patients with nephrotic syndrome.

**Why the Correct Answer is Right**
Corticosteroids can cause a range of side effects, including osteoporosis, glaucoma, and cataract formation. However, the correct answer is related to the development of a specific condition that is not typically associated with corticosteroid therapy. Long-term corticosteroid use can lead to adrenal insufficiency, osteoporosis, and glaucoma, but it is not commonly linked to the development of nephrogenic diabetes insipidus.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because osteoporosis is a well-documented side effect of long-term corticosteroid therapy. Corticosteroids can cause bone loss by inhibiting osteoblast activity and promoting osteoclast activity.
* **Option B:** This option is incorrect because glaucoma is a recognized complication of corticosteroid use, particularly in patients with a history of eye surgery or those who are already at risk for glaucoma. Corticosteroids can increase intraocular pressure.
* **Option C:** This option is incorrect because cataract formation is a known side effect of corticosteroid therapy. Corticosteroids can cause changes in the lens of the eye, leading to cataract formation.

**Clinical Pearl / High-Yield Fact**
It's essential to monitor patients on long-term corticosteroid therapy for potential side effects, including osteoporosis, glaucoma, and cataract formation. Regular bone density scans and eye exams can help detect these complications early.

**Correct Answer:** D.