**Core Concept:** Amyloidosis is a group of diseases characterized by extracellular deposition of amyloid proteins in various tissues and organs, leading to organ dysfunction. In hemodialysis patients, the deposition of amyloid protein may occur in joints, leading to rheumatological manifestations.
**Why the Correct Answer is Right:** The correct answer, Type AA amyloidosis, occurs when amyloid A protein (AA) derived from acute-phase reactants gets deposited in the tissues. This can lead to joint inflammation, swelling, and pain, which are the rheumatological manifestations observed in long-term hemodialysis patients.
**Why Each Wrong Option is Incorrect:**
A. Type AL amyloidosis is the most common type and involves monoclonal immunoglobulin light chains. It does not present with rheumatological manifestations in hemodialysis patients.
B. Type AA amyloidosis is not a correct option because it is the correct answer and has already been explained.
C. Type AA amyloidosis is not correct, as explained before.
D. Type AL amyloidosis is not the correct answer because it does not present with rheumatological manifestations in hemodialysis patients.
**Why the Correct Answer is Right:**
Type AA amyloidosis is the correct answer because it presents with rheumatological manifestations like joint inflammation, swelling, and pain in long-term hemodialysis patients due to the deposition of amyloid A protein in the tissues.
**Clinical Pearl:**
In long-term hemodialysis patients, rheumatological manifestations should prompt the suspicion of Type AA amyloidosis, which should be further investigated with serum amyloid A levels and imaging studies to confirm the diagnosis. Prompt management of the underlying cause (acute phase reaction) can lead to improvement in symptoms and progression of the disease.
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.