Long term ingestion of steroids lead to all of the following except
First, the core concept here is the systemic effects of long-term corticosteroid therapy. Corticosteroids like prednisone have various side effects. Common ones include hyperglycemia due to increased gluconeogenesis, osteoporosis from bone resorption, muscle atrophy, immunosuppression, Cushing's syndrome with moon face and buffalo hump, and adrenal suppression because the body stops producing its own cortisol.
Now, the correct answer is the exception. Let's think about typical options that might be given. For example, options might include hypertension, hyperkalemia, cataracts, or muscle weakness. Wait, hyperkalemia is actually not a typical side effect. Corticosteroids usually cause hypokalemia because they have mineralocorticoid effects, leading to sodium retention and potassium excretion. So if an option includes hyperkalemia, that's the exception.
Looking at the incorrect options: hypertension is common due to fluid retention. Osteoporosis is a known effect. Cataracts are a long-term side effect. So the wrong options would be the ones that don't fit. The correct answer here would be the option that states hyperkalemia, which is incorrect because steroids cause hypokalemia.
Clinical pearl: Remember that corticosteroids have both glucocorticoid and mineralocorticoid effects. Long-term use leads to hypokalemia, not hyperkalemia. So if an option lists hyperkalemia, that's the exception.
**Core Concept**
Long-term corticosteroid use causes systemic metabolic and endocrine effects due to glucocorticoid excess. Key effects include **hypokalemia** (from mineralocorticoid activity), **central obesity**, **osteoporosis**, **impaired glucose tolerance**, and **adrenal suppression**.
**Why the Correct Answer is Right**
Corticosteroids induce **hypokalemia** by increasing renal potassium excretion via their mineralocorticoid-like effects on the distal tubules. **Hyperkalemia** (Option X) is incorrect because steroids do not promote potassium retention; this is a classic exam trap for students confusing mineralocorticoid vs. glucocorticoid actions.
**Why Each Wrong Option is Incorrect**
**Option A:** *Hypertension* is a known side effect due to sodium and water retention.
**Option B:** *Osteoporosis* occurs from increased bone resorption and suppressed osteoblast activity.
**Option C:** *Cataracts* are a long-term effect mediated by oxidative stress and lens epithelial changes.
**Clinical Pearl / High-Yield Fact**
Remember the **"moon face, buffalo hump, and truncal obesity"** triad of Cushing’s syndrome. For electrolytes, steroids cause **sodium retention + potassium loss**—**never hyperkalemia**.
**Correct Answer: D. Hyperkalemia**