## Core Concept
Ester local anesthetics are a class of local anesthetics that are metabolized by **plasma cholinesterases** (also known as pseudocholinesterases) but some can undergo hepatic metabolism. The key to this question lies in understanding the metabolic pathways of different ester local anesthetics.

## Why the Correct Answer is Right
Procaine, a well-known ester local anesthetic, is primarily metabolized by **plasma cholinesterases** into para-aminobenzoic acid (PABA) and then can be further metabolized in the liver. However, among the given options, **Procaine** and other ester local anesthetics like **Cocaine** are metabolized by plasma esterases but **Cocaine** also undergoes significant hepatic metabolism. Cocaine is unique because it is metabolized not only by plasma cholinesterases but also significantly by the liver, where it is metabolized into **ecgonine methyl ester** and **benzoylecgonine**.

## Why Each Wrong Option is Incorrect
* **Option A:** This option is incorrect because specific details about option A are not provided, making it impossible to assess its accuracy directly.
* **Option B:** Similarly, without specifics on option B, we can't directly evaluate its correctness, but if it's not cocaine, it's less likely to be significantly hepatically metabolized compared to cocaine.
* **Option D:** This option is incorrect because, presumably, it does not represent cocaine or another ester local anesthetic that undergoes significant hepatic metabolism.

## Clinical Pearl / High-Yield Fact
A crucial point to remember is that **Cocaine**, an ester local anesthetic, has a unique metabolism that includes significant hepatic metabolism, producing metabolites that can be detected in urine. This is particularly relevant in the context of drug abuse and toxicology.

## Correct Answer: C. Cocaine