The liver biopsy in acute hepatitis due to hepatitis virus is likely to show all of the following, except-
**Core Concept**
Liver biopsy in acute hepatitis due to hepatitis viruses (such as hepatitis B or C) typically reveals liver inflammation and damage. The histopathological changes can vary depending on the stage and severity of the infection.
**Why the Correct Answer is Right**
In acute hepatitis, liver biopsy may show spotty necrosis, lobular inflammation with infiltration of lymphocytes and macrophages, and hepatocellular injury. These changes are a result of the viral infection-induced immune response and subsequent liver cell damage. The affected liver tissue may also exhibit piecemeal necrosis, characterized by the destruction of the limiting plate and the formation of regenerative nodules.
**Why Each Wrong Option is Incorrect**
**Option A:** This option may be a correct aspect of liver biopsy findings in acute hepatitis, as spotty necrosis and lobular inflammation are common features.
**Option B:** This is a plausible option as well, as piecemeal necrosis is a characteristic finding in acute hepatitis.
**Option C:** This option seems incorrect because bridging necrosis is more commonly associated with chronic hepatitis than acute hepatitis.
**Clinical Pearl / High-Yield Fact**
In liver biopsy, bridging necrosis is a hallmark of chronic hepatitis, where there is a more extensive and severe necrotic process, often with fibrosis and architectural distortion.
**Correct Answer:** D.