Lithium directly affects which ion ?
Correct Answer: Sodium
Description: Ans. is 'a' i.e., Sodium Diuretics (paicularly thiazides) decrease the renal excretion of lithium and thus may result in toxicity. This is due to increased reabsorption of Na' and lithium ions (as a compensatory response to excessive loss of Nat). Interactions of lithium Diuretics (thiazide, furosemide) by causing Na+ loss promote proximal tubular reabsorption of Na+ as well as Li - Plasma level of lithium rises. Tetracyclines, NSAIDs and ACE inhibitors cause lithium retention. Lithium tends to enhance insulin/sulphonylurea induced hypoglycemia (lithium has insulin like action on glucose metabolism). Lithium inhibits the action of ADH on distal tubules causes nephrogenic DI. Lithium reduce thyroxine synthesis by interfering iodination of tyrosine.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now