Substance obtained from lipoxygenase pathway and shows chemotaxis to neutrophils is
## Core Concept
The lipoxygenase pathway is involved in the metabolism of arachidonic acid, leading to the production of various leukotrienes. These leukotrienes play significant roles in inflammatory responses, including chemotaxis, which is the movement of cells toward or away from certain chemical stimuli.
## Why the Correct Answer is Right
Leukotriene B4 (LTB4) is a product of the lipoxygenase pathway, specifically derived from arachidonic acid through the action of 5-lipoxygenase. LTB4 is known for its potent chemotactic activity, particularly in attracting neutrophils to sites of inflammation. This action is crucial in the innate immune response, helping to direct white blood cells to areas where they are needed.
## Why Each Wrong Option is Incorrect
- **Option A:** While prostaglandins are derived from arachidonic acid, they are primarily products of the cyclooxygenase pathway, not the lipoxygenase pathway.
- **Option B:** This option might seem plausible but specifying the correct leukotriene is essential.
- **Option C:** Although involved in inflammation, the description specifically points towards a chemotactic substance for neutrophils, which aligns more closely with LTB4.
## Clinical Pearl / High-Yield Fact
A key point to remember is that **Leukotriene B4 (LTB4)** is a powerful chemotactic agent for neutrophils, making it a significant player in the inflammatory process. This is particularly relevant in conditions like asthma, where leukotriene modifiers are used as therapeutic agents.
## Correct Answer: C. Leukotriene B4