Which of the following is increased in lipoprotein lipase deficiency –
**Core Concept**
Lipoprotein lipase (LPL) is an enzyme responsible for the breakdown of triglycerides in lipoproteins, such as very-low-density lipoprotein (VLDL) and chylomicrons. Its deficiency leads to impaired triglyceride metabolism.
**Why the Correct Answer is Right**
In LPL deficiency, the breakdown of triglycerides is impaired, resulting in elevated levels of triglyceride-rich lipoproteins in the bloodstream. This condition is characterized by the accumulation of VLDL and chylomicrons, leading to increased levels of triglycerides. The increased levels of triglycerides can cause pancreatitis, a potentially life-threatening condition.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is not directly related to the consequences of LPL deficiency. While it is true that LPL activity is affected in diabetes, the specific condition of LPL deficiency is characterized by elevated triglyceride levels.
**Option B:** This option is incorrect because LPL deficiency does not directly affect HDL levels. HDL levels are typically influenced by factors such as apoA-I, ABCA1, and LCAT.
**Option C:** This option is incorrect because LPL deficiency primarily affects the breakdown of triglycerides, not the absorption of dietary fats.
**Option D:** This option is incorrect because LPL deficiency does not directly affect the levels of LDL cholesterol.
**Clinical Pearl / High-Yield Fact**
Lipoprotein lipase deficiency is a rare genetic disorder that highlights the importance of triglyceride metabolism in maintaining cardiovascular health. Patients with this condition are at increased risk of pancreatitis and cardiovascular disease.
**Correct Answer:** C. Triglycerides