Ans. D (Hydrogen bond) "Integral protein interacts with hydrophobic region of the membrane through van der waais contact Q & peripheral membrane protein interacts with lipid through ionic or hydrogen bond Q"- Chatterjea & Shinde 7th/12Protein Within Cell MembraneIntegral / Transmembrane Proteins# They interact with the phospholipids and require the use of detergents for their solubilization.Generally span the lipid bilayerQDistributed asymmetrically across the lipid bilayerQAre usually globular proteinsQThey are in amphipathic natureIntegra] proteins are amphipathic in nature and contain both hydrophobic and hydrophilic regionsHydrophilic regions are located at the ends while the transmembrane region i.e. region that traverses the core of the bilayer is composed of a stretch of hydrophobic amino acids.Qintegral protein are in Vander Walls contact with hydro phobic region of membranePeripheral (Extrinsic) ProteinsPeripheral protein present embedded in either the inner or outer leaflet of the lipid hi layer.They do not interact directly with the phospholipids in the bilayer and do not require use of detergents for their releaseThey are weekly bound to the surface of the membrane by ionic interaction or hydrogen bondsAll major lipids in membranes contain both hydrophobic and hydrophilic regions and are therefore termed amphipathicQ."-Harper 28th/ 408Membranes are complex structures composed of lipid, proteins & carbohydrateQ-containing molecules" Harper 28th/407The Major Lipids in Mammalian Membranes are Phospholipids, Glycosphingolipids, & Cholesterol. The amount of each depends upon the type of cell, but in the majority of cases phospholipids are the most abundant. Example of the major cases membrane phospholipids are : phosphatidyicholine(Lecithin), phosphatidylethanolamine, phosphatidylinositol, phosphatidylserineQ.Membranes are asymmetric structuresQ