## Core Concept
The life cycle of filarial parasites in mosquitoes involves the development of microfilariae into infective third-stage larvae. This process is crucial for the transmission of filariasis to humans. The mosquito acts as an intermediate host where the parasite undergoes developmental stages.
## Why the Correct Answer is Right
The correct sequence in the mosquito involves:
1. **Ingestion of microfilariae**: When an infected human is bitten by a mosquito, the microfilariae are ingested.
2. **Development into first-stage larvae (L1)**: Inside the mosquito, microfilariae develop into first-stage larvae.
3. **Molting to second-stage larvae (L2)**: The L1 larvae then molt into second-stage larvae.
4. **Molting to third-stage larvae (L3)**: Finally, the L2 larvae molt into third-stage larvae, which are infective to humans.
## Why Each Wrong Option is Incorrect
- **Option A:** This option is incorrect because it does not accurately describe the developmental stages of filarial parasites in mosquitoes.
- **Option B:** This option is incorrect as it might suggest an incomplete or incorrect sequence of developmental stages.
- **Option D:** This option is incorrect because it likely represents an alternative incorrect sequence or stages.
## Clinical Pearl / High-Yield Fact
A key point to remember is that the mosquito's role in filarial transmission is critical, and the development of microfilariae into third-stage larvae within the mosquito is necessary for the parasites to become infective to humans. The lifecycle in the mosquito typically takes about 10-14 days, depending on the species of filaria and the ambient temperature.
## Correct Answer: C.
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