Physiology Liddle syndrome is caused by a genetic defect in A Na-K-2Cl co-transpoer in the thick ascending limb of loop of henle B Na-Cl cotranspoer in the distal tubule C ENasodium Channel in collecting duct/tubule D The aquaporin 2 (AQP2) channel in collecting duct 💡 Explanation Liddle syndrome is caused by a genetic defect in ✓ Correct Answer: C. ENasodium Channel in collecting duct/tubule