All of the following are seen in Lichen planus except?
**Core Concept**
Lichen planus is a chronic inflammatory mucocutaneous disease characterized by the presence of a band-like inflammatory infiltrate at the dermo-epidermal junction, leading to the formation of colloid bodies and other histopathological features. The granular cell layer is typically preserved in lichen planus.
**Why the Correct Answer is Right**
The granular cell layer is not absent in lichen planus. Instead, the disease is characterized by the presence of a band-like inflammatory infiltrate at the dermo-epidermal junction, which leads to the formation of colloid bodies. The granular cell layer is preserved in lichen planus, and the disease typically affects the basal layer of the epidermis. The presence of colloid bodies, also known as Civatte bodies, is a hallmark of lichen planus.
**Why Each Wrong Option is Incorrect**
**Option A:** Max-Joseph spaces are actually seen in pemphigus, not lichen planus. In pemphigus, the acantholysis leads to the formation of intercellular spaces, which are referred to as Max-Joseph spaces.
**Option B:** Civatte or colloid bodies are indeed seen in lichen planus, as mentioned earlier. These bodies are formed due to the necrosis of the basal cells and are a characteristic feature of the disease.
**Option C:** Koebner's phenomenon is also seen in lichen planus. It refers to the appearance of lesions at the site of trauma, which is a characteristic feature of the disease.
**Clinical Pearl / High-Yield Fact**
Lichen planus can affect the oral mucosa, skin, and other mucous membranes. The disease is characterized by the presence of a band-like inflammatory infiltrate at the dermo-epidermal junction, leading to the formation of colloid bodies and other histopathological features. The disease is often associated with autoimmune disorders and can be treated with topical corticosteroids and other immunosuppressive agents.
**β Correct Answer: D. Absent granular cell layer**