**Core Concept**
The Lewis triple response, also known as the triple response of Lewis, is a physiological response to a gentle stroking of the skin with a firm brush. It is characterized by a red line, a flare, and a wheal. This response is mediated by the release of histamine from mast cells, leading to increased blood flow and permeability.

**Why the Correct Answer is Right**
The correct answer is related to the mechanism of histamine release. The stroking of the skin causes mechanical damage to the mast cells, leading to the release of histamine. Histamine then acts on H1 receptors, causing vasodilation and increased permeability, resulting in the red line, flare, and wheal. This response is an example of a type of immediate hypersensitivity reaction.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not accurately describe the mechanism of the Lewis triple response.
**Option B:** This option is incorrect because it refers to a different type of physiological response.
**Option C:** This option is incorrect because it is not related to the Lewis triple response.

**Clinical Pearl / High-Yield Fact**
The Lewis triple response is a classic example of an immediate hypersensitivity reaction, which is mediated by the release of histamine from mast cells. This type of reaction is often seen in conditions such as allergic rhinitis and anaphylaxis.

**Correct Answer:** D. Histamine release from mast cells.