Lesion of globus pallidus causes
**Core Concept**
Lesions to the globus pallidus, a structure within the basal ganglia, can lead to significant motor impairments due to its role in regulating movement and motor control. The globus pallidus is involved in the indirect pathway of the basal ganglia circuitry, which helps to inhibit motor activity.
**Why the Correct Answer is Right**
Lesions to the globus pallidus can lead to an overactivity of the subthalamic nucleus, resulting in an imbalance in the basal ganglia circuitry. This imbalance can cause an increase in motor activity, leading to symptoms such as dystonia, chorea, and tremors. The globus pallidus is also involved in the regulation of dopamine release, and lesions can disrupt this process, leading to an abnormal increase in dopamine levels, which can further exacerbate motor symptoms.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is not a direct consequence of a lesion to the globus pallidus. While the globus pallidus is involved in motor control, lesions to other structures within the basal ganglia, such as the substantia nigra, can lead to more prominent motor symptoms.
**Option B:** This option is not accurate. Lesions to the globus pallidus do not typically lead to an increase in muscle tone. Instead, they can cause a decrease in muscle tone, leading to symptoms such as hypotonia.
**Option C:** This option is not a direct consequence of a lesion to the globus pallidus. While the globus pallidus is involved in motor control, lesions to other structures within the basal ganglia, such as the thalamus, can lead to more prominent cognitive symptoms.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that lesions to the globus pallidus can lead to an overactivity of the subthalamic nucleus, resulting in an imbalance in the basal ganglia circuitry. This can cause an increase in motor activity, leading to symptoms such as dystonia, chorea, and tremors.
**Correct Answer: B. Hypotonia**