Medicine Lesch-Nyhan syndrome is due to the deficiency of which enzyme? A Glucose 6- phosphatase B Glutathione reductase C PRPP glutamyl-amidotransferase D Hypoxanthine-guanine phosphoribosyl transferase 💡 Explanation Lesch-Nyhan syndrome is due to the deficiency of which enzyme? ✓ Correct Answer: D. Hypoxanthine-guanine phosphoribosyl transferase