Biochemistry Lesch-Nyhan syndrome is caused by deficiency of which enzyme? A Orotate Phosphoribosyl transferase B Uracil Phosphoribosyl transferase C Quinolinate Phosphoribosyl transferase D Hypoxanthine-guanine Phosphoribosyl transferase (HGPRT) 💡 Explanation Lesch-Nyhan syndrome is caused by deficiency of which enzyme? ✓ Correct Answer: D. Hypoxanthine-guanine Phosphoribosyl transferase (HGPRT)