**Core Concept**
Left-sided portal hypertension refers to the increased pressure in the portal vein and its tributaries on the left side of the liver, often due to thrombosis or obstruction of the left portal vein. This condition can lead to varices, ascites, and splenomegaly.

**Why the Correct Answer is Right**
The correct treatment for left-sided portal hypertension is usually surgical intervention, specifically left portal vein thrombectomy or revascularization. This procedure aims to restore blood flow to the left liver lobe, reducing portal pressure and alleviating symptoms. The surgical approach is often preferred over endovascular methods due to the risk of bleeding and the need for precise restoration of blood flow to the affected area.

**Why Each Wrong Option is Incorrect**
**Option A:** Medical management with beta-blockers and endoscopic variceal ligation is not sufficient for left-sided portal hypertension, as it does not address the underlying cause of portal vein obstruction.
**Option B:** Transjugular intrahepatic portosystemic shunt (TIPS) is a treatment option for portal hypertension, but it is typically reserved for cases where surgical intervention is not feasible or has failed.
**Option C:** Liver transplantation may be considered in cases of advanced liver disease or when other treatments have failed, but it is not the primary treatment for left-sided portal hypertension.

**Clinical Pearl / High-Yield Fact**
When managing portal hypertension, it's essential to identify the underlying cause and tailor treatment accordingly. In cases of left-sided portal hypertension, surgical intervention is often the most effective approach to restore blood flow and alleviate symptoms.

**Correct Answer: B. Transjugular intrahepatic portosystemic shunt (TIPS).**