Leber’s optic neuropathy-

A. Typically presents in the fourth decade of life

B. Males do not transmit the disease

C. Is inherited in autosomal X-link fashion

D. The optic disc is pale early in the disease

Correct Answer: Males do not transmit the disease

Description: Leber's hereditary optic neuropathy is a mitochondrial disorder. Since mitochondrial DNA is exclusively derived from mothers, males do not transmit the disease. The optic disc becomes pale and atrophic in late atrophic phase (not early).

Category: Ophthalmology

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