**Core Concept**
CO2 is the most commonly used insufflation gas in laparoscopic procedures due to its low solubility in blood and tissues. This property allows for rapid expansion and deflation of the abdominal cavity, minimizing the risk of gas absorption and embolism.

**Why the Correct Answer is Right**
CO2 is used because it is non-flammable and non-toxic, reducing the risk of fire during electrosurgical procedures. Additionally, its low solubility in blood minimizes the risk of gas embolism, which can be a serious complication. The high solubility of N2 and O2 in blood makes them less suitable for insufflation.

**Why Each Wrong Option is Incorrect**
**Option A:** Nitrous oxide is a potent vasodilator and can cause respiratory depression, making it unsuitable for laparoscopic procedures.
**Option B:** Oxygen is highly soluble in blood and can cause gas embolism if used for insufflation.
**Option C:** Nitrogen is non-toxic but has a high solubility in blood, making it less suitable for insufflation.

**Clinical Pearl / High-Yield Fact**
In laparoscopic procedures, it's essential to maintain a safe level of CO2 insufflation pressure to avoid complications such as gas embolism and abdominal wall complications.

**Correct Answer:** C. Nitrogen is non-toxic but has a high solubility in blood, making it less suitable for insufflation.