Lamivudine acts at which of the following enzymes?
Correct Answer: Both of the above
Description: Lamivudine inhibits HBV DNA polymerase and HIV reverse transcriptase by competing with deoxycytidine triphosphate for incorporation into the viral DNA, resulting in chain termination. Lamivudine achieves 3-4 log decreases in viral replication in most patients and suppression of HBV DNA to undetectable levels in about 44% of patients. Ref: Katzung 11th edition Chapter 49.
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Pharmacology
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