Which of the following is not seen in kwashiorkor?
**Core Concept**
Kwashiorkor is a form of severe malnutrition characterized by edema, growth retardation, and impaired immune function. It is caused by a lack of sufficient protein intake, often seen in children in developing countries. The pathophysiology of kwashiorkor involves inadequate production of albumin, a crucial protein responsible for maintaining osmotic balance in the body.
**Why the Correct Answer is Right**
The correct answer is related to the pathophysiology of kwashiorkor. In kwashiorkor, the liver produces insufficient amounts of albumin, leading to hypoalbuminemia. This results in decreased oncotic pressure, causing fluid to leak from the bloodstream into the interstitial space, leading to edema. However, the liver's ability to synthesize other essential proteins, such as clotting factors, is preserved.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because edema is a hallmark feature of kwashiorkor, resulting from hypoalbuminemia and decreased oncotic pressure.
**Option B:** This option is incorrect because impaired immune function is a characteristic of kwashiorkor, leading to increased susceptibility to infections.
**Option C:** This option is incorrect because growth retardation is a common feature of kwashiorkor, resulting from inadequate nutrition and protein deficiency.
**Clinical Pearl / High-Yield Fact**
In contrast to kwashiorkor, marasmus is another form of severe malnutrition characterized by muscle wasting and lack of edema, despite severe malnutrition. This is due to the body's ability to mobilize stored protein and fat reserves, but not producing new proteins.
**Correct Answer:** D.